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The Influence of the Xymedon Сonjugate with l-Methionine on the Regeneration of Schmidtea mediterranea Planarians

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Abstract

The effect of the Xymedon conjugate with methionine on blastema regeneration in Schmidtea mediterranea planarians was investigated. It was established that the preparation has low toxicity towards planarians, which is evidenced by its CL50 values (lethal concentration). The results of the vital computer morphometry and flow cytofluorometry confirm that Xymedon with methionine induces regeneration at high concentrations only: 0.01 g/100 mL, 0.05 g/100 mL, and 0.1 mg/100 mL. Low concentrations of the preparation have no influence on blastema regeneration in planarians.

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References

  1. Izmailov, S. G., Izmajlov, G. A., Aver’yanov, M. Y., & Reznik, V. S. (2001). Xymedon in clinical practice. Nizhny Novgorod: NGMA.

    Google Scholar 

  2. Vyshtakaliuk, A. B., Nazarov, N. G., Porfiriev, A. G., Zueva, I. V., Minnechanova, O. A., Mayatina, O. V., Reznik, V. S., Zobov, V. V., & Nicolskyi, E. E. (2015). The influence of the Xymedon preparation (Hydroxyethyldimethyldihydropyrimidine) on the rat liver recovery under toxic damage induced by carbon tetrachloride. Dokl Biochem Biophys, 462(1), 143–146. https://doi.org/10.1134/S1607672915030011.

    Article  Google Scholar 

  3. Vyshtakaliuk, A. B., Semenov, V. E., Zobov, V. V., Galyametdinova, I. V., Gumarova, L. F., Parfenov, A. A., Nazarov, N. G., Lenina, O. A., Kondrashova, S. A., Latypov, S. K., Cherepnev, G. V., Shashin, M. S., & Nazarov, N. G. (2017). Synthesis and primary evaluation of the hepatoprotective properties of novel pyrimidine derivatives. Russian Journal of Bioorganic Chemistry, 43(5), 604–611. https://doi.org/10.1134/S106816201704015X.

    Article  Google Scholar 

  4. Porfiriev, A. G., Yuganova, K. S., Vyshtakaliuk, A. B., Zobov, V. V., & Reznik, V. S. (2017). The influence of the Xymedon preparation on the regeneration of Girardia tigrina planarians. BioNanoScience, 7(1), 237–239. https://doi.org/10.1007/s12668-016-0311-0.

    Article  Google Scholar 

  5. Povysheva, T. V., Semenov, V. E., Galyametdinova, I. V., ReznikVS, K. K. S., Kolesnikov, P. E., & Chelyshev, Y. A. (2016). New Xymedon analogues for stimulation of posttraumatic regeneration of the spinal cord in rats. Bull Exp Biol Med, 162(2), 220–224. https://doi.org/10.1007/s10517-016-3580-2.

    Article  Google Scholar 

  6. Vyshtakalyuk, A., Parfenov, A., Gumarova, L., Nazarov, N., Zobov, V., Galyametdinova, I., & Semenov, V. (2017). Comparative evaluation of hepatoprotective activity of Xymedon preparation derivatives with ascorbic acid and methionine. BioNanoScience, 7(4), 616–622. https://doi.org/10.1007/s12668-017-0461-8.

    Article  Google Scholar 

  7. Alvarado, S. A., Newmark, P. A., Robb, S. M., & Juste, R. (2002). The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration. Development, 129, 5659–5665. https://doi.org/10.1242/dev.00167.

    Article  Google Scholar 

  8. Yermakova, O. N., Yermakov, A. M., Tiras, K. P., & Lednev, V. V. (2009). Melatonin effect on the regeneration of the flatworm Girardia tigrina. Russ J Dev Biol, 40(6), 382–385. https://doi.org/10.1134/S1062360409060083.

    Article  Google Scholar 

  9. Tiras, K. P. (1986). Morphogenesis and ways of regeneration in planarians. Zh Obshch Biol, 47(1), 103–109.

    MathSciNet  Google Scholar 

  10. Kutsenko, S. A. (2004). Bases of toxicology. Foliant: St. Petersburg.

    Google Scholar 

  11. Rombke, J., & Moltmann, J. F. (1996). Applied ecotoxicology. CRC Lewis Publishers.

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Funding

The authors gratefully acknowledge for financial support from the government assignment for Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences.”

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Authors and Affiliations

  1. Department of Zoology and General Biology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya str., Kazan, Russia, 420008

    Andrey Porfiriev, Dayana Sharafutdinova, Alexander Belyaev, Valeria Shubina, Anatoly Golubev & Vladimir Zobov

  2. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan, Russian Federation, 420088

    Andrey Parfenov, Alexandra Vyshtakaliuk, Vladimir Zobov & Vyacheslav Semenov

Authors
  1. Andrey Porfiriev
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  2. Dayana Sharafutdinova
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  3. Alexander Belyaev
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  4. Andrey Parfenov
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  5. Valeria Shubina
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  6. Anatoly Golubev
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  7. Alexandra Vyshtakaliuk
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  8. Vladimir Zobov
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  9. Vyacheslav Semenov
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Equal contribution.

Corresponding author

Correspondence to Andrey Porfiriev.

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The authors declare that they have no conflict of interest.

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Schmidtea mediterranea planarians are well-known objects for the study of regeneration in the world. The formation of the blastema is always reached by cutting off the edges of the planarian body. Blastema formation occurs due to migration and division of neoblasts—pluripotent cells. Planarians have a very simple nervous system and do not have the sensitivity like mammals. All planarians used in the experiment survived and restored their front ends with eyes.

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Porfiriev, A., Sharafutdinova, D., Belyaev, A. et al. The Influence of the Xymedon Сonjugate with l-Methionine on the Regeneration of Schmidtea mediterranea Planarians. BioNanoSci. 10, 397–402 (2020). https://doi.org/10.1007/s12668-020-00735-z

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